In the Naruto lore, the Hokage's bond with Kurama is one of the source material's most intriguing arcs. Naruto suffered as a kid, being viewed as an outsider by Konoha after his parents died, sacrificing themselves against the Nine Tails Demon Fox.

Heavenly Stardust Reveals Kurama's Energy May Have Harmed Naruto

Naruto had harnessed Kurama's chakra to become a godlike soldier. It's what helped him surpass Sage Mode, coming close to being a warrior akin to the Sage of the Six Paths. This allowed Naruto to fight off numerous aliens from the Ōtsutsuki clan.

Kurama messing with Naruto's physiology does make sense as these beasts are weapons of mass destruction. They pack nuclear power to destroy nations, and possibly worlds.

Kurama's Poisoning Could Tease Other Dangers

some shocking news has developed in Chapter 3 of Naruto:

Sasuke's Story -- The Uchiha and the Heavenly Stardust regarding Naruto and the fox's bond.